Stable Growth of Wild-Type Hepatitis A Virus in Cell Culture
نویسندگان
چکیده
منابع مشابه
Stable growth of wild-type hepatitis A virus in cell culture.
Human wild-type (wt) hepatitis A virus (HAV), the causative agent of acute hepatitis, barely grows in cell culture and in the process accumulates attenuating and cell culture-adapting mutations. This genetic instability of wt HAV in cell culture is a major roadblock to studying HAV pathogenesis and producing live vaccines that are not overly attenuated for humans. To develop a robust cell cultu...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2006
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.80.3.1352-1360.2006